This study investigated the relationship between the career burnout, couple burnout and psychological well-being scores of teachers. The study further investigated whether psychological well-being have mediating role on the relationship between career burnout and couple burnout. The data of the study were collected from 830 teachers. The sample consisted of 349 male and 481 female who are married or in romantic relationship in the metropolitan district of Adana, Turkey. The data were collected by using “Personal Information Form”, “Burnout Scale-Short Version”, “Couple Burnout Scale-Short Version”, “Psychological Well-Being Scale”. The correlation analysis was used to determine the relationships between career burnout, couple burnout and psychological well-being. Then, the structural equality model was used to analyze whether teachers' psychological well-being had a mediating role between career and couple burnout. The study showed that a significant positive relationship was observed between career burnout and couple burnout. Moreover, psychological wellbeing was negatively correlated with career burnout and couple burnout. Finally, the study concluded that psychological well-being plays a partial role in the relationship between teachers' couples and career burnout.