It is known that 21st century skills, especially knowledge, skills, character and meta-learning dimensions, are needed by people in our developing and changing age. The aim of this study is to examine the four-dimensional 21st century skills of students studying in a high school in terms of some variables. The study was conducted according to mixed research method and enriched design was used. The study was carried out with 179 students (98 female, 81 male) at different levels studying in a multi-programme high school in Gaziantep province. "Personal Information Form", "Questionnaire for Determining Students' Views on 21st Century Skills" and "Form for Determining Teachers' Views on Students' 21st Century Skills" were used as data collection tools in the study. When the results of the applied measurement tools were examined, it was determined that the students had 21st century skills (knowledge, skills, character, meta-learning) at an average level, and there was no differentiation according to gender and class level.